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Basic Studies

(Click following titles for corresponding clinical report)

File extraction code：4321

A. Pharmacology/ Pharmacodynamic Studies

1. Kanglaite Injection - Study of General Pharmacology

2. Kanglaite Injection Pharmacological Study

3. Progress in Pharmacodynamics and Clinical Studies of Active Components of Coix Seed (Semen Coicis) and Its Preparation - Kanglaite Injection (KLT)

4. Antitumor Action of Kanglaite Injection against Xenograft Human Tumor Models

5. Antitumor Activity of Kanglaite Injection in Animals with Transplanted Tumors

6. The Protective and Therapeutic Effects of Kanglaite Injection on Leukopenia Induced by Chemotherapy

7. A Study of Kanglaite Injection Treated Human Erythroleukemia K562 Cells with TUNEL and Annexin V Labeling Technique -Flow Cytometric Scan Methods

8. Experimental Study of Counteractive Effect of Kanglaite Injection on Cancer Cachexia

9. Impact of Kanglaite Injection on Mice Immunological Function

10. Study Report on the Effect of Kanglaite Injection on SW1990 Human Pancreatic Cancer Xenograft in Nude Mice

11. The Effects of Kanglaite Injection on Radiosusceptibility of Renal Carcinoma Cells

12. The Effects of Kanglaite Injection on the Sentization of Biological Therapy of Colon cells

13. Effect of Kanglaite Injection on B16 Melanoma Lung Metastasis in Mice

14. Study on Kanglaite Injection to Resist LA795 Lung Metastasis

15. Primary Pharmacodynamic Trial Data and Literature (Human Pancreatic Cancer)

16. Primary Pharmacodynamic Test Data and Literature (Human Breast Cancer)

17. The Effect of Kanglaite Injection on the Generation and Secretion of IL-1 of Mice Macrophage

18. Coix Seed Extract, a Commonly Used Treatment for Cancer in China, Inhibit NFkB and Protein Kinase C Signaling

1. Kanglaite Injection - Study of General Pharmacology

B. Pharmacokinetic Studies

1. Research on Pharmacokinetics and Bioavailability of Coix Seed Oil

2. Study on the Effect of Coix Seed Extract on Enzymes of Lipometabolism and Glycometabolism

3. Phase I Study of KLT in Patients with Solid Tumors Refractory to Standard Therapy

1. Research on Pharmacokinetics and Bioavailability of Coix Seed Oil

C. Toxicology Studies

1. Kanglaite Injection - Acute Toxicity Study in Mice with Administration by the Intravenous and Intraperitoneal Routes

2. Kanglaite Injection - Toxicity Study in Beagle Dogs with Administration by Intravenous Route for 45 Consecutive Days

3. Kanglaite Injection - Study of Development Toxicity (Embryo/ Feral Toxicty and Teratogenicity)

4. Evaluation of Kanglaite Injection for Gene Mutagenecity in Ames Test

5. Kanglaite Injection -Chromosome Aberration Test in Cultured Chinese Hamster Lung Cells

6. Kanglaite Injection Micronucleus Test in Mice

1. Kanglaite Injection - Acute Toxicity Study in Mice with Administration by the Intravenous and Intraperitoneal Routes

D. Mechanistic Studies

2. Kanglaite Injection - Allergy Test in Guinea Pigs

4. Kanglaiye Injection - Irritation Test in Quadriceps Femoris Muscles of Rabbites

1. Effects of Kanglaite Injection on Cancer Cell Proliferation Cycle

2. Effects of Kanglaite Injedction on Reversing Multiple Drug Resistance (MDR) of Tumor Cells

3. Effect of Kanglaite Injection on Angiogenesis

4. Study on the Apoptosis of Renal Cancer Cells and the Expression of FAS/APO-1 and BCL-2 Genes Induced by Kanglaite Injection

5. A cDNA Microarray Study of the Effect of Kanglaite Injection in Inducing Apoptosis of PATU-8988 Human Pancreatic Cancer Cells

6. Induction of the Apoptosis of Renal Carcinoma Cells and Regulation of the Expression of P53 and BCL-2 Genes by Kanglaite Injection

7. The Effect of Kanglaite Injection on Expression of MUCI MUCIN and Its Biological Meaning

8. Study of Kanglaite Injection on Expression of Fas/Apo-1, FasL and PCNA in Kidney Cancer Cells

9. Effects of Kanglaite on Apoptosis and Apoptotic Protein Procaspase-3 and Capase-9 Expression in Hepatic Carcinoma BEL-7404 Cells

10. Coix Seed Extract, a Commonly Used Treatment for Cancer in China Inhibits NFKB and Protein Kinase C Signaling

1. Effects of Kanglaite Injection on Cancer Cell Proliferation Cycle

E. Other Studies

1. Kanglaite Injection -Blood Vessel Irritation Test in Beagle Dogs

3. Kanglaie Injection - Hemolysis Test

5. Kanglaite Injection - Pyrogen Test

1. Kanglaite Injection -Blood Vessel Irritation Test in Beagle Dogs

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